Corviral | Inkmed

CORVIRAL^® is a unique product with a specially developed formula to help the body optimize the immune defense, through an array of key beneficial ingredients. These help modulate the immune system and target viral particles. (Research studies in support of each point below are listed under the main text).

Extracts from the quinine tree /Cinchona/ and the artemisinin-containing sweet wormwood /Artemisia annua/ have anti-inflammatory and immunomodulatory effects. They counteract viral entry within cellular membranes, thus inhibiting pathogenic replication cycles.

The hawthorn extract /Crataegus monogyna/ is known for its cardioprotective effects. Quercetin also found in high concentrations of hawthorn and is a zinc ionophore. The combined interactions between zinc and Hawthorn /Crataegus spp/ have a synergistic effect when applied in a single formula. First, it is important to understand that zinc is a key mineral that is part of nearly 10% of all the proteins which are currently in our body, so it is indirectly involved with many functions, some of which relate to the immune system and its regulation and response. In addition to that, zinc was found to have a blocking or disruptive effect on viral replication via four mechanisms, however in order to be able to do so it needs to be inside the cell. This is where the Hawthorn plays an important role, because it contains the flavonoid Quercetin – a type of molecule known as a zinc ionophore. What it does is to keep the ion channels on cell surfaces open so that zinc can enter the intercellular space and exert its antiviral effect.

The apple pectin in the formula contributes to the health of the digestive system. Pectin also helps protects the cardiovascular system by helping to lower the levels of bad cholesterol and triglycerides in the plasma.

Another important ingredient with a powerful immunostimulatory effect is ginger extract /Zingiber officinale/ which in combination with zinc and selenium minerals, as well as vitamin C, which are all essential for a well-functioning immune system.

A further herbal extract recruited to help control COVID-19 is diammonium glycyrrhizinate, an extract from liquorice roots. Liquorice /Glycyrrhiza/ glabra, has long been used against coughs and colds as well as to settle disturbed digestion, while diammonium glycyrrhizinate has anti- inflammatory activity and is used to treat liver damage caused by hepatitis “B”. Professor Hong Ding of Wuhan University has proposed a combination of diammonium glycyrrhizinate and vitamin C as a COVID-19 therapy. This approach became popular through social media and reporting in publications such as the Health Times (Jiankang Shibao). While it has not been officially recommended, clinical trials have recently been approved.

According to some investigators (prof. Diana Ionova from “Hospital Lozenec”, Sofia, Bulgaria) the selenium deficiency in the population partially explains the quick outbreak of COVID 19 both in China (due to the combination of protein shortage, harsh continental climate and overpopulation) and in Northern Italy (due the recently experienced “water stress” which lead to accumulation of oxidative radicals in the population as a result of the depletion of selenium-containing enzymes.) The recommended daily supplementation with selenium is between 50-200 mcg per day depending on the severity of the deficiency.

Anti-viral herbal medicines have been used in many historic epidemics, including during the previous two coronavirus outbreaks (SARS-CoV in 2013 and MERS- CoV in 2012), seasonal epidemics caused by influenza viruses and dengue virus. Extracts from Lycoris radiate, Artemisia annua and Lindera aggregate, and the natural products isolated from Isatis indigotica and Torreya nucifera showed anti-SARS effects.

Further Geranium /Pelargonium sidoides/ roots and dandelion / Taraxcum/ have been research proven to have anti-influenza activities, as they inhibit virus entry and key viral enzyme activities.

The combination of all of these herbal extracts have an overall protective effect on multiple organ systems and modulatory effect on the immune system, with special emphasis on enhancing natural anti-viral defense mechanisms and inhibiting viral lifecycle.

CORVIRAL^® is recommended to be taken as soon as the first flu-like symptoms are present (not before). It is recommended that you consult your medical practitioner before starting its use.

CORVIRAL^® is a product unique with its composition and could be applied in various medical conditions caused by infections and with an inflammatory profile.

PUBLISHED ARTICLES / RESEARCH

https://www.nature.com/articles/s41477-020-0628-0

The following are all the active ingredients in the formula and some of the published research that has been done over the years researching their mechanisms.

Glycyrrhiza glabra / Женскобиле

https://www.sciencedirect.com/topics/agricultural-and-biological-science...

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Artemisia annua / Сладъкпелин

https://www.sciencedirect.com/topics/medicine-and-dentistry/artemisia-annua

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Extract from the leafs of Cinchona spp. / ЕкстрактотлистанаCinchonaspp.

https://www.sciencedirect.com/topics/agricultural-and-biological-science...

https://www.sciencedirect.com/topics/chemistry/cinchona-alkaloid

https://www.webmd.com/vitamins/ai/ingredientmono-406/cinchona

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Hawthorn (Crataegus spp.) containing Quercitin / Екстракт глог

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249900/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891531/

https://www.hindawi.com/journals/ecam/2013/149363/

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Taraxacum officinale / Екстракт глухарче

https://www.sciencedirect.com/science/article/abs/pii/S0378874107004850

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Аscorbic Acid (Vitamin C) / Витамин С

https://www.ncbi.nlm.nih.gov/pubmed/29099763

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024758/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006137/

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Galacturonic acid / D-D-Галактуроновакиселина

https://www.sciencedirect.com/topics/neuroscience/galacturonic-acid

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Pectin (from Apples) / Пектин(ябълков)

https://www.sciencedirect.com/topics/neuroscience/galacturonic-acid

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Citrus Aurantium / Горчивпортокал

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954905/

https://www.semanticscholar.org/paper/Immune-enhancement-effects-and-ext...

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Zingiber officinale / Джинджифил

https://www.ncbi.nlm.nih.gov/pubmed/19589240

https://www.ncbi.nlm.nih.gov/pubmed/28877566

https://www.ncbi.nlm.nih.gov/pubmed/29039335

https://www.ncbi.nlm.nih.gov/pubmed/27089418

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106649/

https://www.ncbi.nlm.nih.gov/pubmed/28842272

https://www.ncbi.nlm.nih.gov/pubmed/27559855

https://www.ncbi.nlm.nih.gov/pubmed/23123794

https://www.sciencedirect.com/science/article/abs/pii/S0883944112001566

https://www.sciencedirect.com/science/article/abs/pii/S0883944110000080

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Radix Isatidis / Радиксисатидис

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943010/

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Radix Lycoris (radiata) / Ликорисрадикс

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138836/

https://www.mdpi.com/1420-3049/18/3/2458/pdf

https://www.sciencedirect.com/science/article/abs/pii/S0367326X15000052

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Lindera aggregata / Линдераагрегата

https://www.tandfonline.com/doi/abs/10.1076/phbi.36.3.222.6349

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Isatis indigotica / Багрилнасърпица

https://www.ncbi.nlm.nih.gov/pubmed/16115693

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Torreya nucifera / Toреянуцифера

https://www.ncbi.nlm.nih.gov/pubmed/20934345

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Pelargonium / Екстрактотмушкато

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183890/

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Zinc / Цинк

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277319/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628855/

https://www.bbc.com/news/health-21372790

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Sodium Selenite / Натриевселенит

Selenium in the Immune System

https://www.ncbi.nlm.nih.gov/pubmed/12730442

Selenium, immune function and resistance to viral infections

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1747-0080.2008.00260.x

The recommended CORVIRAL^® daily intake is 1-2 capsules, 3 times per day (the total of 3 to 6 capsules per day). If necessary, the dosage could be increased by your medical supervisor according to your individual condition.

CORVIRAL^® is a registered trademark of INKMED and BRIOGEN TRADING – BULGARIA.

Manufactured in cooperation with INKMED and BRIOGEN at its cGMP certified manufacturing facility located in the industrial zone just outside of Sofia, Bulgaria, European Union.

Corviral